ad90b88734
Moved 43 weight-based drug entries out of calculators.js string literals
into a structured JSON reference. Renderers now iterate JSON → S.drugRow.
Sections extracted (43 drugs):
- anaphylaxis (7), sedation (11), agitation (11), antiemetics (7), seizure (7)
Out of scope: seizure refractory drips (compound strings), NRP, antimicrobial
empiric regimens (already structured), airway/cardiac/tox/trauma/respiratory
/sepsis/burns sections (fine as-is or no drugs).
New:
- public/data/drugs.json — { version, last_reviewed, sections.<key>.drugs[] }
- public/js/drugs-loader.js — fetches JSON on boot, exposes window._DRUGS +
window._DRUGS_READY Promise. Non-fatal: each calc function has a matching
*_FALLBACK constant so a 404 on drugs.json doesn't break anything.
Schema:
- dose_mg_per_kg | dose_mg_per_kg_low/high (for ranges) | max_mg | unit |
route | notes | source | optional special-cases (weight bands, age-dep text)
Added one unit test asserting drugs.json loads + has all 5 sections with
non-empty drugs arrays. 37/37 unit tests + 26/26 Playwright e2e tests pass.
498 lines
15 KiB
JSON
498 lines
15 KiB
JSON
{
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"version": "1.0",
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"last_reviewed": "2026-04-20",
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"sections": {
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"anaphylaxis": {
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"drugs": [
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{
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"name": "Epinephrine IM",
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"dose_mg_per_kg": 0.01,
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"max_mg": 0.5,
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"unit": "mg",
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"route": "IM",
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"notes": "1:1000 (1 mg/mL), lateral thigh. May repeat q5-15 min.",
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"concentration": "1:1000",
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"source": "ASCIA 2021"
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},
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{
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"name": "Normal saline bolus",
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"dose_mg_per_kg": 20,
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"max_mg": null,
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"unit": "mL",
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"route": "IV/IO",
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"notes": "Repeat up to 60 mL/kg for hypotension",
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"source": "ASCIA 2021"
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},
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{
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"name": "Diphenhydramine",
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"dose_mg_per_kg": 1.25,
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"max_mg": 50,
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"unit": "mg",
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"route": "IV/IM/PO",
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"notes": "H1 blocker. NOT first-line — adjunct only",
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"source": "AAP/ACAAI"
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},
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{
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"name": "Ranitidine",
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"dose_mg_per_kg": 1,
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"max_mg": 50,
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"unit": "mg",
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"route": "IV over 5 min",
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"notes": "H2 blocker. Optional adjunct",
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"source": "AAP/ACAAI"
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},
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{
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"name": "Dexamethasone",
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"dose_mg_per_kg": 0.6,
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"max_mg": 16,
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"unit": "mg",
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"route": "IV/IM/PO",
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"notes": "Prevents biphasic reaction (4-6 hrs later)",
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"source": "AAP/ACAAI"
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},
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{
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"name": "Methylprednisolone",
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"dose_mg_per_kg": 2,
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"max_mg": 125,
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"unit": "mg",
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"route": "IV",
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"notes": "Alternative steroid",
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"source": "AAP/ACAAI"
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},
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{
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"name": "Glucagon",
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"dose_mg_per_kg": 0.02,
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"max_mg": 1,
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"unit": "mg",
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"route": "IV/IM",
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"notes": "For patients on beta-blockers not responding to epi",
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"source": "ASCIA 2021"
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}
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]
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},
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"sedation": {
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"drugs": [
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{
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"name": "Ketamine IV",
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"display": "Ketamine",
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"dose_mg_per_kg_low": 1.5,
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"dose_mg_per_kg_high": 2,
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"max_mg_low": 100,
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"max_mg_high": 150,
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"unit": "mg",
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"route": "IV",
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"onset": "1 min",
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"duration": "15-30 min",
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"notes": "Dissociative. Preserves airway reflexes.",
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"source": "AAP sedation guideline"
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},
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{
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"name": "Ketamine IM",
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"display": "",
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"dose_mg_per_kg_low": 4,
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"dose_mg_per_kg_high": 5,
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"max_mg_low": 300,
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"max_mg_high": 400,
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"unit": "mg",
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"route": "IM",
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"onset": "3-5 min",
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"duration": "30-60 min",
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"notes": "Give atropine 0.01 mg/kg to reduce secretions.",
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"source": "AAP sedation guideline"
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},
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{
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"name": "Midazolam IV",
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"display": "Midazolam",
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"dose_mg_per_kg_low": 0.05,
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"dose_mg_per_kg_high": 0.1,
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"max_mg_low": 2,
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"max_mg_high": 5,
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"unit": "mg",
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"route": "IV",
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"onset": "2-3 min",
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"duration": "30-60 min",
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"notes": "Anxiolysis. Titrate q3-5 min.",
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"source": "AAP sedation guideline"
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},
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{
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"name": "Midazolam IN/PO",
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"display": "",
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"dose_mg_per_kg": 0.5,
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"max_mg": 20,
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"unit": "mg",
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"route": "IN/PO",
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"onset": "10-15 min",
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"duration": "30-60 min",
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"notes": "IN (max 10 mg / naris) or PO (max 20 mg).",
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"source": "AAP sedation guideline"
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},
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{
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"name": "Propofol",
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"display": "Propofol",
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"dose_mg_per_kg": 1,
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"max_mg": 40,
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"unit": "mg",
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"route": "IV",
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"onset": "30 sec",
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"duration": "5-10 min",
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"notes": "Short procedures. Causes apnea — manage airway.",
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"source": "AAP sedation guideline"
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},
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{
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"name": "Fentanyl IV",
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"display": "Fentanyl",
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"dose_mg_per_kg": 1,
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"max_mg": 100,
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"unit": "mcg",
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"route": "IV",
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"onset": "2-3 min",
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"duration": "30-60 min",
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"notes": "Analgesic. Often combined with midazolam.",
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"source": "AAP sedation guideline"
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},
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{
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"name": "Fentanyl IN",
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"display": "",
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"dose_mg_per_kg": 2,
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"max_mg": 100,
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"unit": "mcg",
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"route": "IN",
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"onset": "5-10 min",
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"duration": "30-60 min",
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"notes": "Intranasal.",
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"source": "AAP sedation guideline"
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},
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{
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"name": "Nitrous oxide",
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"display": "Nitrous oxide",
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"dose_mg_per_kg": null,
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"max_mg": null,
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"unit": "mix",
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"dose_display": "50:50 or 70:30 mix",
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"route": "Inhaled",
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"onset": "2-5 min",
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"duration": "5 min off",
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"notes": "Self-administered via demand valve. Anxiolysis + mild analgesia.",
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"source": "AAP sedation guideline"
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},
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{
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"name": "Dexmedetomidine IN",
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"display": "Dexmedetomidine",
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"dose_mg_per_kg_low": 2,
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"dose_mg_per_kg_high": 3,
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"max_mg_low": 100,
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"max_mg_high": null,
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"unit": "mcg",
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"route": "IN",
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"onset": "15-30 min",
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"duration": "60-90 min",
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"notes": "Intranasal. No respiratory depression. Good for imaging.",
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"source": "AAP sedation guideline"
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},
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{
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"name": "Naloxone",
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"display": "Naloxone",
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"dose_mg_per_kg": 0.1,
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"max_mg": 2,
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"unit": "mg",
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"route": "IV/IM/IN",
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"reverses": "Opioids (fentanyl, morphine)",
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"notes": "Max 2 mg. Repeat q2-3 min. Duration shorter than opioids — monitor for re-sedation.",
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"source": "AAP sedation guideline"
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},
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{
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"name": "Flumazenil",
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"display": "Flumazenil",
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"dose_mg_per_kg": 0.01,
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"max_mg": 0.2,
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"unit": "mg",
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"route": "IV",
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"reverses": "Benzodiazepines (midazolam)",
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"notes": "Max 0.2 mg single dose. Repeat q1 min to max 1 mg total. Risk of seizures — use cautiously.",
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"source": "AAP sedation guideline"
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}
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]
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},
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"agitation": {
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"drugs": [
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{
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"name": "Lorazepam PO",
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"display": "Lorazepam",
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"step": 2,
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"dose_mg_per_kg": 0.05,
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"max_mg": 2,
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"unit": "mg",
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"route": "PO",
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"notes": "0.05 mg/kg. May repeat in 30 min.",
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"source": "AAP/ACEP agitation"
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},
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{
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"name": "Midazolam PO",
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"display": "Midazolam",
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"step": 2,
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"dose_mg_per_kg": 0.5,
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"max_mg": 10,
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"unit": "mg",
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"route": "PO",
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"notes": "0.5 mg/kg (max 10 mg)",
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"source": "AAP/ACEP agitation"
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},
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{
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"name": "Midazolam IN",
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"display": "Midazolam",
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"step": 2,
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"dose_mg_per_kg": 0.3,
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"max_mg": 10,
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"unit": "mg",
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"route": "IN (5 mg/mL)",
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"notes": "0.3 mg/kg split between nares (max 10 mg)",
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"source": "AAP/ACEP agitation"
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},
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{
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"name": "Olanzapine (ODT)",
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"display": "Olanzapine (ODT)",
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"step": 2,
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"dose_mg_per_kg": null,
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"max_mg": null,
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"unit": "mg",
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"route": "PO / ODT",
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"dose_display_if_under_30kg": "2.5-5 mg",
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"dose_display_if_30kg_or_more": "5-10 mg",
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"notes": "Age ≥6 yr. Avoid IM + benzo combo (risk of resp depression).",
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"source": "AAP/ACEP agitation"
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},
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{
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"name": "Diphenhydramine PO",
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"display": "Diphenhydramine",
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"step": 2,
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"dose_mg_per_kg": 1,
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"max_mg": 50,
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"unit": "mg",
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"route": "PO",
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"notes": "1 mg/kg. Adjunct only; sedating.",
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"source": "AAP/ACEP agitation"
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},
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{
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"name": "Midazolam IV/IM",
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"display": "Midazolam",
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"step": 3,
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"dose_mg_per_kg": 0.1,
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"max_mg": 5,
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"unit": "mg",
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"route": "IV / IM",
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"notes": "0.05-0.1 mg/kg IV, 0.1-0.15 mg/kg IM (max 10 mg)",
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"source": "AAP/ACEP agitation"
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},
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{
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"name": "Lorazepam IV/IM",
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"display": "Lorazepam",
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"step": 3,
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"dose_mg_per_kg": 0.1,
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"max_mg": 4,
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"unit": "mg",
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"route": "IV / IM",
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"notes": "0.05-0.1 mg/kg (max 4 mg). May cause resp depression.",
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"source": "AAP/ACEP agitation"
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},
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{
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"name": "Haloperidol",
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"display": "Haloperidol",
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"step": 3,
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"dose_mg_per_kg": 0.05,
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"max_mg": null,
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"unit": "mg",
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"route": "IM / IV",
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"dose_display_if_under_40kg": "0.025-0.075 mg/kg",
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"dose_display_if_40kg_or_more": "2.5-5 mg",
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"notes": "Avoid <3 yr. Risk: QT, EPS, NMS. ECG if repeated.",
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"source": "AAP/ACEP agitation"
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},
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{
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"name": "Olanzapine IM",
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"display": "Olanzapine",
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"step": 3,
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"dose_mg_per_kg": null,
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"max_mg": null,
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"unit": "mg",
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"route": "IM",
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"dose_display_if_under_40kg": "2.5-5 mg",
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"dose_display_if_40kg_or_more": "5-10 mg",
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"notes": "Avoid benzo co-administration (resp depression, hypotension)",
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"source": "AAP/ACEP agitation"
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},
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{
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"name": "Ketamine IM",
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"display": "Ketamine",
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"step": 3,
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"dose_mg_per_kg": 4,
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"max_mg": 500,
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"unit": "mg",
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"route": "IM",
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"notes": "4-5 mg/kg IM (rescue for severe excited delirium). Monitor airway.",
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"source": "AAP/ACEP agitation"
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},
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{
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"name": "Droperidol",
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"display": "Droperidol",
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"step": 3,
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"dose_mg_per_kg": 0.05,
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"max_mg": null,
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"unit": "mg",
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"route": "IM / IV",
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"dose_display_prefix": "0.03-0.07 mg/kg",
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"notes": "Effective but QT concern — get ECG.",
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"source": "AAP/ACEP agitation"
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}
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]
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},
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"antiemetics": {
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"drugs": [
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{
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"name": "Ondansetron",
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"dose_mg_per_kg": 0.15,
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"max_mg": 8,
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"unit": "mg",
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"route": "PO / ODT / IV",
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"weight_band_dose": {
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"under_15kg": "2 mg",
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"15_to_30kg": "4 mg",
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"30kg_or_more": "8 mg"
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},
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"notes": "First-line. Max single 8 mg. Repeat q8h. QT prolongation — avoid with other QT drugs. <6 mo: limited data.",
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"source": "AAP gastroenteritis; Lexicomp"
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},
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{
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"name": "Metoclopramide",
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"dose_mg_per_kg": 0.15,
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"max_mg": 10,
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"unit": "mg",
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"route": "IV / IM / PO",
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"notes": "0.1-0.15 mg/kg (max 10 mg). Give with diphenhydramine to prevent EPS / dystonia.",
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"source": "Lexicomp"
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},
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{
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"name": "Dimenhydrinate",
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"dose_mg_per_kg": 1.25,
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"max_mg": 50,
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"unit": "mg",
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"route": "PO / IV / IM / PR",
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"notes": "1.25 mg/kg (max 50 mg) q6h. ≥2 yr.",
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"source": "Lexicomp"
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},
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{
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"name": "Diphenhydramine",
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"dose_mg_per_kg": 1,
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"max_mg": 50,
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"unit": "mg",
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"route": "PO / IV / IM",
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"notes": "1 mg/kg (max 50 mg) q6h. Adjunct, sedating.",
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"source": "Lexicomp"
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},
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{
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"name": "Promethazine",
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"dose_mg_per_kg": 0.25,
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"max_mg": 25,
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"unit": "mg",
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"route": "PO / IV / IM",
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"notes": "0.25-1 mg/kg. <strong>CONTRAINDICATED <2 yr</strong> (resp depression). Tissue injury if IV extrav.",
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"source": "Lexicomp"
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},
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{
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"name": "Dexamethasone",
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"dose_mg_per_kg": 0.15,
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"max_mg": 10,
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"unit": "mg",
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"route": "IV / PO",
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"notes": "Adjunct, esp. chemo-induced. 0.15 mg/kg (max 10 mg).",
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"source": "Lexicomp"
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},
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{
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"name": "Scopolamine patch",
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"dose_mg_per_kg": null,
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"max_mg": null,
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"unit": "mg",
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"dose_display": "1.5 mg patch",
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"route": "Transdermal",
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"notes": "≥12 yr. Motion sickness. Apply 4h before exposure.",
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"source": "Lexicomp"
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}
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]
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},
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"seizure": {
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"drugs": [
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{
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"name": "Lorazepam",
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"phase": "1st benzo",
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"dose_mg_per_kg": 0.1,
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"max_mg": 4,
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"unit": "mg",
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"route": "IV / IO",
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"label_suffix": " <span style=\"color:#065f46;font-weight:600;\">(IV preferred)</span>",
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"notes": "Slow push over 1-2 min.",
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"source": "AES 2016; ESETT 2019"
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},
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{
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"name": "Midazolam",
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"phase": "1st benzo",
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"dose_mg_per_kg": 0.2,
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"max_mg": 10,
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"unit": "mg",
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"route": "IM / IN / buccal",
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"notes": "Use 5 mg/mL concentrate for IN; split between nares.",
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"source": "AES 2016; ESETT 2019"
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},
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{
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"name": "Diazepam",
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"phase": "1st benzo",
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"dose_mg_per_kg": 0.5,
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"max_mg": 20,
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"unit": "mg",
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"route": "PR",
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"notes": "Only if no IV/IM/IN access.",
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"source": "AES 2016"
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},
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{
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"name": "Levetiracetam",
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"phase": "2nd-line",
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"dose_mg_per_kg": 60,
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"max_mg": 4500,
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"unit": "mg",
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"route": "IV over 5-15 min",
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"label_suffix": " <span style=\"color:#065f46;font-weight:600;\">(preferred)</span>",
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"notes": "Best tolerability. No ECG monitoring needed.",
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"source": "ESETT 2019"
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},
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{
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"name": "Fosphenytoin",
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"phase": "2nd-line",
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"dose_mg_per_kg": 20,
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"max_mg": 1500,
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"unit": "mg PE",
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"route": "IV over 10 min",
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"notes": "Max rate 3 mg PE/kg/min. Monitor ECG, BP. Avoid if cardiac dysrhythmia.",
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"source": "ESETT 2019"
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},
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{
|
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"name": "Valproic acid",
|
|
"phase": "2nd-line",
|
|
"dose_mg_per_kg": 40,
|
|
"max_mg": 3000,
|
|
"unit": "mg",
|
|
"route": "IV over 10 min",
|
|
"notes": "<strong>Avoid <2 yr, hepatic / mitochondrial disease, pregnancy.</strong>",
|
|
"source": "ESETT 2019"
|
|
},
|
|
{
|
|
"name": "Phenobarbital",
|
|
"phase": "2nd-line",
|
|
"dose_mg_per_kg": 20,
|
|
"max_mg": 1000,
|
|
"unit": "mg",
|
|
"route": "IV over 20 min",
|
|
"notes": "Last-choice 2nd line. High risk of resp depression + hypotension.",
|
|
"source": "AES 2016"
|
|
}
|
|
]
|
|
}
|
|
}
|
|
}
|